Building a tumor atlas: integrating single-cell RNA-Seq data with spatial transcriptomics in pancreatic ductal adenocarcinoma

“Building a tumor atlas: integrating single-cell RNA-Seq data with spatial transcriptomics in pancreatic ductal adenocarcinoma” by Reuben Moncada, Marta Chiodin, Joseph C. Devlin, Maayan Baron, Cristina H. Hajdu, Diane Simeone, and Itai Yanai. https://doi.org/10.1101/254375 I selected this article for review for a few reasons: I thought the spatial aspects of the work were intriguing. I have an interest in methods that use single cell data to deconvolve bulk samples. I was curious about heterogeneity in this disease based on some of our previous work with FNA-derived PDX models. »