deep learning , unsupervised , acute myeloid leukemia , cancer , transcriptome

DeepProfile: Deep learning of patient molecular profiles for precision medicine in acute myeloid leukemia

Update: The preprint discussed in this has been updated since these reviews were posted. These reviews may no longer apply to the current version of the manuscript. “DeepProfile: Deep learning of patient molecular profiles for precision medicine in acute myeloid leukemia” by Ayse Berceste Dincer, Safiye Celik, Naozumi Hiranuma, and Su-In Lee. https://doi.org/10.1101/278739 I selected this article for review for a few reasons: I was intrigued by the compilation of a large dataset from many small datasets before applying unsupervised learning, which we have had success with in other settings. »
Casey S. Greene Author image
single cell , deconvolution , cancer , transcriptome

Building a tumor atlas: integrating single-cell RNA-Seq data with spatial transcriptomics in pancreatic ductal adenocarcinoma

Update: This paper has now been published in Nature Biotechnology. “Building a tumor atlas: integrating single-cell RNA-Seq data with spatial transcriptomics in pancreatic ductal adenocarcinoma” by Reuben Moncada, Marta Chiodin, Joseph C. Devlin, Maayan Baron, Cristina H. Hajdu, Diane Simeone, and Itai Yanai. https://doi.org/10.1101/254375 I selected this article for review for a few reasons: I thought the spatial aspects of the work were intriguing. I have an interest in methods that use single cell data to deconvolve bulk samples. »
Casey S. Greene Author image